HERV-K np9 and HERV-R env: Two endogenous retrovirus products with potential Pathogenic roles in pediatric acute lymphoblastic leukemia.
Noha GaberAhmed Samir AbdelhafizNivin Abdel-AzimAzza ShiblLamiaa FadelZeinab Korany HassanEman Hassan AhmedPublished in: International journal of immunopathology and pharmacology (2024)
The overexpression of HERV-K np9 and HERV-R env in pediatric ALL patients suggest their potential role in leukemogenesis. Our findings also suggest a possible link between HSV infection and HERV reactivation in this population. Future investigations are needed to understand the precise roles of these genes and viral infections in the development of ALL.
Keyphrases
- acute lymphoblastic leukemia
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- sars cov
- peritoneal dialysis
- transcription factor
- genome wide
- current status
- patient reported outcomes
- allogeneic hematopoietic stem cell transplantation
- herpes simplex virus
- young adults
- genome wide identification