Login / Signup

Biomimetic Total Synthesis of Rhodonoids C and D, and Murrayakonine D.

Aaron J DayHiu C LamChristopher J SumbyJonathan H George
Published in: Organic letters (2017)
A divergent, three-step total synthesis of rhodonoids C and D has been achieved using a biosynthetically inspired, acid-catalyzed cascade cyclization of an epoxy-chromene that involves the presumed intermediacy of o-quinone methides. Application of a similar strategy also allowed synthesis of the alkaloid murrayakonine D.
Keyphrases
  • room temperature