AT1R/GSK-3β/mTOR Signaling Pathway Involved in Angiotensin II-Induced Neuronal Apoptosis after HIE Both In Vitro and In Vivo.
Wei SiBanghui LiCameron LenahanShirong LiRan GuHao QuLu WangJiapeng LiuTian TianQian Wangnull XikeWangXiao HuGang ZuoPublished in: Oxidative medicine and cellular longevity (2020)
Ang II increased neuronal apoptosis through the AT1R/GSK-3β/mTOR signaling pathway after experimental HIE both in vitro and in vivo, and Ang II may serve as a novel therapeutic target to ameliorate brain injury after HIE.
Keyphrases
- angiotensin ii
- pi k akt
- signaling pathway
- cell cycle arrest
- brain injury
- cerebral ischemia
- cell proliferation
- subarachnoid hemorrhage
- angiotensin converting enzyme
- vascular smooth muscle cells
- oxidative stress
- endoplasmic reticulum stress
- induced apoptosis
- epithelial mesenchymal transition
- cell death
- diabetic rats
- blood brain barrier