Ultrasmall Cortex Moutan Nanoclusters for the Therapy of Pneumonia and Colitis.
Yuan LiXiangmei LiuYufeng ZhengYu ZhangZhaoyang LiZhenduo CuiHui JiangShengli ZhuShui-Lin WuPublished in: Advanced healthcare materials (2023)
Infectious pneumonia and colitis are hard to be treated due to tissue infection, mucosal immune disorders, and dysbacteriosis. Although conventional nanomaterials can eliminate infection, they also damage normal tissues and intestinal flora. Herein, this work reports bactericidal nanoclusters formed through self-assembly for efficient treatment of infectious pneumonia and enteritis. The ultrasmall (about 2.3 nm) cortex moutan nanoclusters (CMNCs) has excellent antibacterial, antiviral, and immune regulation activity. The formation of nanoclusters is analyzed from the molecular dynamics mainly through the binding between polyphenol structures through hydrogen bonding and ππ stacking interaction. CMNCs have enhanced tissue and mucus permeability ability compared with natural CM. CMNCs precisely targeted bacteria due to polyphenol-rich surface structure and inhibited broad spectrum of bacteria. Besides, they killed H1N1 virus mainly through the inhibition of the neuraminidase. These CMNCs are effective in treating infectious pneumonia and enteritis relative to natural CM. In addition, they can be used for adjuvant colitis treatment by protecting colonic epithelium and altering the composition of gut microbiota. Therefore, CMNCs showed excellent application and clinical translation prospects in the treatment of immune and infectious diseases.
Keyphrases
- molecular dynamics
- sensitive detection
- infectious diseases
- ulcerative colitis
- gene expression
- early stage
- fluorescent probe
- oxidative stress
- emergency department
- stem cells
- endothelial cells
- combination therapy
- bone marrow
- high resolution
- density functional theory
- drug delivery
- transcription factor
- community acquired pneumonia
- newly diagnosed
- adverse drug
- wound healing