SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27.
Elizabeth R GallagherErika L F HolzbaurPublished in: Autophagy (2023)
SQSTM1/p62: Sequestosome-1; HSP27: Heat shock protein 27; LLPS: liquid-liquid phase separation; iPSC: induced pluripotent stem cell; PB1: Phox and Bem1p; FRAP: fluorescence recovery after photo-bleaching; ATG: autophagy-related; ALS: amyotrophic lateral sclerosis.
Keyphrases
- heat shock protein
- amyotrophic lateral sclerosis
- stem cells
- heat shock
- high glucose
- cell death
- diabetic rats
- hydrogen peroxide
- oxidative stress
- heavy metals
- endoplasmic reticulum stress
- drug induced
- signaling pathway
- single molecule
- ionic liquid
- induced pluripotent stem cells
- endothelial cells
- risk assessment
- cell therapy
- electron transfer
- mesenchymal stem cells