Synthetic resin acid derivatives selectively open the hKV 7.2/7.3 channel and prevent epileptic seizures.
Nina E OttossonMalin Silverå EjnebyXiongyu WuArgel Estrada-MondragonMichelle NilssonUrban KarlssonMelanie SchuppSalomé RognantThomas Andrew JeppsPeter KonradssonFredrik ElinderPublished in: Epilepsia (2021)
The described resin acid derivatives hold promise for new antiseizure medications, with reduced risk for adverse effects compared with retigabine.