Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas.

Gabriela Sarti KinkerGlauco Akelinghton Freire VitielloAriane Barros DinizMariela Pires Cabral-PiccinPedro Henrique Barbosa PereiraMaria Letícia Rodrigues CarvalhoWallax Augusto Silva FerreiraAlexandre Silva ChavesAmanda RondinelliArianne Fagotti GusmãoAlexandre DefelicibusGabriel Oliveira Dos SantosWarley Abreu NunesLaura Carolina López ClaroTalita Magalhães BernardoRicardo Tadashi NishioAdhemar Monteiro PachecoAna Carolina LausLidia Maria Rebolho Batista ArantesJulia Lima FleckVictor Hugo Fonseca de JesusAndré de MoriczRicardo WeinlichFelipe José Fernandez CoimbraVladmir Cláudio Cordeiro de LimaTiago da Silva Medina

Published in: Gut (2023)

We provided a framework for understanding the biological role of PDAC-associated TLSs and revealed their potential to guide the selection of patients for future immunotherapy trials.

Keyphrases

immune response
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
risk assessment
toll like receptor
mass spectrometry
single cell
patient reported outcomes
inflammatory response
current status