Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT.
Peter Stephen PatrickKrishna K KolluriMay Zaw ThinAdam EdwardsElizabeth K SageTom SandersonBenjamin D WeilJohn C DicksonMark F LythgoeMark LowdellSam M JanesTammy L KalberPublished in: Stem cell research & therapy (2020)
89Zr-oxine labelling and PET-CT imaging present a potential method of evaluating the biodistribution of new cell therapies in patients, including MSCTRAIL. This offers to improve understanding of cell therapies, including mechanism of action, migration dynamics, and inter-patient variability.
Keyphrases
- pet ct
- positron emission tomography
- pet imaging
- end stage renal disease
- single cell
- cell therapy
- newly diagnosed
- ejection fraction
- chronic kidney disease
- mesenchymal stem cells
- prognostic factors
- peritoneal dialysis
- case report
- stem cells
- computed tomography
- risk assessment
- patient reported outcomes
- bone marrow
- human health