Alveolar bone histological necrosis observed prior to extractions in patients, who received bone-targeting agents.

Ourania Nicolatou-GalitisErofili PapadopoulouEmmanouil VardasMaria KouriDimitra GalitiEvangelos GalitisKonstantina-Eleni AlexiouKostas TsiklakisAlexandros ArdavanisEvangelia RazisIlias AthanasiadisStavroula DroufakouAmanda PsyrriMichalis V KaramouzisHelena LinardouDanai DalianiDimitrios TzanninisSotirios SachanasKonstantinos LaschosMarie-Christine KyrtsonisFotini AntoniouApostolos LaskarakisStyllianos GiassasAdamantia NikolaidiGeorge RigakosAnna NtokouCesar A MiglioratiCarla I Ripamonti

Published in: Oral diseases (2020)

Pain, swelling, purulence, fistula, and numbness were significantly associated with complete bone histological necrosis prior to extractions and increased MRONJ development. Research is justified to explore whether histological necrosis represents an early stage of osteonecrosis.

Keyphrases

bone mineral density
early stage
soft tissue
bone loss
bone regeneration
chronic pain
postmenopausal women
neuropathic pain
squamous cell carcinoma
spinal cord injury
lymph node
postoperative pain