Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer.

Milly J McAllisterPamela McCallAshley DicksonMark A UnderwoodDitte AndersenElizabeth HolmesElke MarkertHing Y Leung Joanne Edwards

Published in: Prostate cancer and prostatic diseases (2020)

Combined pARser81 and pARser213 provides a novel prognostic biomarker for castrate-resistant disease and a potential predictive and therapeutic target for prostate cancer. Further studies will be required to investigate the combined effects of targeting AR and PI3K/AKT signalling.

Keyphrases

prostate cancer
pi k akt
signaling pathway
radical prostatectomy
protein kinase
cell proliferation
cell cycle arrest
cell death
risk assessment