Stereoselective Construction of the ABCDE Pentacyclic Motif of Phainanoids via Norrish-Yang Photocyclization Reaction.

Yi-Ke ZhouZhen-Yu ZhangHao-Yuan LiuYuan-He LiZhong-Chao ZhangJia-Hua ChenZhen Yang

Published in: Organic letters (2024)

A Norrish-Yang photocyclization reaction has been applied to regio- and stereoselective construction of the ABCDE pentacyclic motif of natural product phainanoids. The observed substrate conformation control implicates this powerful reaction could be applied to the construction of structurally diverse natural product scaffolds.

Keyphrases

electron transfer
molecular dynamics simulations
amino acid
crystal structure