Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.
Srikant RangarajuEric B DammerSyed Ali RazaTianwen GaoHailian XiaoRanjita BetarbetDuc M DuongJames A WebsterChadwick M HalesJames J LahAllan I LeveyNicholas T SeyfriedPublished in: Molecular neurodegeneration (2018)
We report a comprehensive proteomic study of adult mouse microglia derived from acute neuroinflammation and AD models, representing a valuable resource to the neuroscience research community. We highlight shared and unique microglial proteomic changes in acute neuroinflammation aging and AD mouse models and identify novel roles for microglial proteins in human neurodegeneration.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- liver failure
- neuropathic pain
- respiratory failure
- label free
- drug induced
- endothelial cells
- traumatic brain injury
- aortic dissection
- mouse model
- healthcare
- high resolution
- mass spectrometry
- spinal cord
- genome wide
- cognitive decline
- cerebral ischemia
- induced pluripotent stem cells
- brain injury
- intensive care unit
- subarachnoid hemorrhage