Obesity, which is one of the most important noncommunicable diseases, has become an epidemic. With the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, the collision of these two health risks has increased the threat of adverse events and serious threats to public health. In this review, the impact of obesity on COVID-19 severity and mortality is presented. The mechanism by which obesity increases susceptibility and severity is discussed. As a low-grade inflammatory disease, obesity provides a pro-inflammatory milieu by which adipose tissue expressing angiotensin converting enzyme 2, which is known as a receptor for severe acute respiratory syndrome coronavirus 2, works as a viral reservoir. Finally, the role of metabolic and bariatric surgeries during the COVID-19 era will be discussed.
Keyphrases
- coronavirus disease
- respiratory syndrome coronavirus
- insulin resistance
- weight loss
- sars cov
- metabolic syndrome
- adipose tissue
- high fat diet induced
- type diabetes
- low grade
- weight gain
- public health
- bariatric surgery
- angiotensin converting enzyme
- high grade
- high fat diet
- angiotensin ii
- skeletal muscle
- cardiovascular disease
- cardiovascular events
- oxidative stress
- risk factors