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Multiple perianal ulcers due to suppositories.

Francesco SavoiaAndrea SechiMichela TabanelliSilvia ZagoMiriam LeuzziCarlotta BaraldiAnnalisa Patrizi
Published in: The Australasian journal of dermatology (2018)
We report a case of long-standing inexplicable perianal ulcers. After exclusion of an inflammatory, infectious or neoplastic origin, a thorough personal history revealed that for many years the patient had been using analgesic suppositories containing indomethacin, caffeine, and prochlorperazine dimaleate, four to five times a week, for migraine. On stopping the suppositories, there was complete healing within 12 weeks. We hypothesize that vasoconstriction and vascular damage were the pathogenetic mechanisms behind the perianal ulcers.
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