Activating transcription factor 3 inhibits NF‑κB p65 signaling pathway and mediates apoptosis and cell cycle arrest in cervical cancer cells.
Amirhossein Akbarpour ArsanjaniHaniyeh AbueiAbbas Behzad-BehbahaniZahra BagheriRita ArabsolgharAli FarhadiPublished in: Infectious agents and cancer (2022)
ATF3 acts as a tumor suppressor factor in HPV16-infected Ca Ski cells and exerts anti-cancer effects on HPV16-related cervical cancer cells potentially by hindering cell growth and inducing cell cycle arrest through the down-regulation of NF-κB. Our results suggest that ATF3 induction or NF-κB suppression may be useful targets for HPV16-related cervical cancer prevention and treatment.
Keyphrases
- cell cycle arrest
- pi k akt
- signaling pathway
- transcription factor
- induced apoptosis
- cell death
- cell proliferation
- epithelial mesenchymal transition
- high grade
- endoplasmic reticulum stress
- lps induced
- oxidative stress
- dna binding
- inflammatory response
- nuclear factor
- toll like receptor
- replacement therapy
- protein kinase