Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD.
Arthur M LeeYunwen XuStephen R HooperAlison G AbrahamJian HuRui XiaoMatthew B MathesonCelina BrunsonEugene P RheeJosef CoreshRamachandran S VasanSarah J SchraubenPaul L KimmelBradley A WaradySusan L FurthErum A HartungMichelle R Denburgnull nullPublished in: Clinical journal of the American Society of Nephrology : CJASN (2023)
Several metabolites were associated with neurocognitive dysfunction in pediatric CKD, implicating gut microbiome-derived substances, mitochondrial dysfunction and altered energy metabolism, circulating toxins, and redox homeostasis.