Cytokine and phenotypic cell profiles in human cutaneous leishmaniasis caused by Leishmania donovani.
Hiruni WijesooriyaThisum Nilakshi SamaranayakeNadira Darshani KarunaweeraPublished in: PloS one (2023)
The overall immunophenotypic profile suggests that LCL observed in the country is the result of a balancing immune response between pro-inflammatory and regulatory mediators. The mediators which showed distinct profiles in patients warrant further investigation as potential candidates for immunotherapeutic approaches. A comparison with visceral leishmaniasis caused by the same species, would provide further evidence on the differential role of these mediators in the resulting clinical phenotype.
Keyphrases
- immune response
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- cell therapy
- single cell
- transcription factor
- dendritic cells
- inflammatory response
- climate change
- patient reported outcomes
- induced pluripotent stem cells
- bone marrow
- trypanosoma cruzi