T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.

Elisabeth AxZala JevnikarAleksander Cvjetkovic Carina MalmhällHenric OlssonMadeleine Rådinger Cecilia Lässer

Published in: Respiratory research (2020)

Together, the results suggest that epithelial EVs are involved in airway inflammation and that the EV proteome may be used for discovery of disease-specific mechanisms and signatures which may enable a precision medicine approach to the treatment of asthma.

Keyphrases

chronic obstructive pulmonary disease
small molecule
lung function
high throughput
genome wide
gene expression
combination therapy
cystic fibrosis