Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
Regitze Gyldenholm SkalsMaria Lukács KrogagerEmil Vincent R AppelTheresia M SchnurrChristian Theil HaveGunnar GislasonHenrik Enghusen PoulsenLars KøberThomas EngstrømSteen StenderTorben HansenNiels GrarupChristina Ji-Young LeeCharlotte AnderssonChristian Torp-PedersenPeter E WeekePublished in: PloS one (2021)
Among patients referred for coronary angiography, only a strong genetic predisposition to insulin resistance was associated with risk of coronary artery disease and with a greater disease burden.
Keyphrases
- coronary artery disease
- insulin resistance
- end stage renal disease
- adipose tissue
- ejection fraction
- metabolic syndrome
- type diabetes
- chronic kidney disease
- genome wide
- percutaneous coronary intervention
- newly diagnosed
- cardiovascular events
- polycystic ovary syndrome
- skeletal muscle
- prognostic factors
- risk factors
- peritoneal dialysis
- cardiovascular disease
- high fat diet induced
- heart failure
- patient reported outcomes
- copy number
- gene expression
- atrial fibrillation
- weight loss