Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging.

Liao ZhangChenxu YanYutao ZhangDun MaJialiang HuangZijun ZhaoYining TaoCaiqi LiuJuan LiWei-Hong Zhu Zhi-Qian Guo

Published in: Chemical communications (Cambridge, England) (2023)

Herein, we design a novel "crossbreeding" dye (BC-OH) within the second near-infrared (NIR-II) window based on BODIPY and chromene chromophores. BC-OH can serve as a platform to construct activatable NIR-II probes with small spectral crosstalk, thereby making a breakthrough in imaging in vivo H 2 O 2 fluctuation in an APAP-induced liver injury model with high signal-to-background ratio.

Keyphrases

fluorescent probe
living cells
fluorescence imaging
photodynamic therapy
optical coherence tomography
small molecule
high resolution
magnetic resonance
magnetic resonance imaging
drug delivery
dual energy
computed tomography