Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging.
Liao ZhangChenxu YanYutao ZhangDun MaJialiang HuangZijun ZhaoYining TaoCaiqi LiuJuan LiWei-Hong ZhuZhi-Qian GuoPublished in: Chemical communications (Cambridge, England) (2023)
Herein, we design a novel "crossbreeding" dye (BC-OH) within the second near-infrared (NIR-II) window based on BODIPY and chromene chromophores. BC-OH can serve as a platform to construct activatable NIR-II probes with small spectral crosstalk, thereby making a breakthrough in imaging in vivo H 2 O 2 fluctuation in an APAP-induced liver injury model with high signal-to-background ratio.