Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin.
Elisa FontanaJeff MeyersAlberto F SobreroTimothy J IvesonAnthony F ShieldsGilles ManceauTakayuki YoshinoIoannis SouglakosElizabeth C SmythFlorian LordickMarkus MöhlerAnne GirautAndrea HarkinRoberto LabiancaJeffrey MeyerhardtThierry AndréIoannis BoukovinasSara LonardiMark SaundersDewi VernereyEiji OkiVassilis GeorgouliasIrit Ben-AharonQian ShiPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Young age is negatively prognostic in high-risk stage III CRC and associated with significantly higher relapse rate; this is despite better treatment adherence and higher administered treatment intensity, suggesting more aggressive disease biology.