A simulation study on estimating biomarker-treatment interaction effects in randomized trials with prognostic variables.

Published in: Trials (2018)

We recommend undertaking an adequate literature search before data analysis to derive information about potential prognostic variables and to gain power for detecting true interaction effects and pre-specifying analyses to avoid selective reporting and increased false-positive rates.

Keyphrases

data analysis
emergency department
adverse drug
replacement therapy
drug induced