Assessment of stromal tumor infiltrating lymphocytes and immunohistochemical features in invasive micropapillary breast carcinoma with long-term outcomes.
Frederik DemanKevin PunieAnnouschka LaenenPatrick NevenEva OldenburgerAnn SmeetsInes NevelsteenChantal Van OngevalAdinda BatenTimothy FaesMelissa ChristiaensHilde JanssenCaroline WeltensChristine DesmedtHans WildiersGiuseppe FlorisPublished in: Breast cancer research and treatment (2020)
Clinicopathological features, geographical distribution of sTILs and TAPC are similar between pure and non-pure IMPCs. Despite a high proportion of grade 3 tumors and lymph node involvement, we observed a low rate of distant recurrences and breast cancer-related death in this cohort of stage I-III IMPCs treated with primary surgery. Caution in interpretation of the observed prognostic correlations is required given the very low number of events, warranting validation in other cohorts.