Why Do Mice Overeat High-Fat Diets? How High-Fat Diet Alters the Regulation of Daily Caloric Intake in Mice.
Julia A LicholaiKatrina P NguyenWambura C FobbsCorbin J SchusterMohamed A AliAlexxai V KravitzPublished in: Obesity (Silver Spring, Md.) (2018)
An HFD did not disrupt regulation of total daily caloric intake, even when up to 90% of total calories came from the HFD. However, HFDs increased daily caloric intake when provided ad libitum and were readily consumed by mice outside of their normal feeding cycle. Ad libitum HFDs appear to induce overconsumption beyond the mechanisms that regulate daily caloric intake.