Combined Exposure of Activated Intestinal Epithelial Cells to Nondigestible Oligosaccharides and CpG-ODN Suppresses Th2-Associated CCL22 Release While Enhancing Galectin-9, TGFβ, and Th1 Polarization.

Saskia Adriana OverbeekAtanaska I KostadinovaMartine A BoksSimone M HayenWilco de JagerBelinda Van't LandLéon M J KnippelsJohan GarssenLinette E M Willemsen

Published in: Mediators of inflammation (2019)

IL1α enhanced CCL20 and Th2-associated CCL22 release by IFNγ/TNFα-activated IEC. Combined scGOS/lcFOS and CpG-ODN exposure suppressed CCL22, while maintaining high CCL20, TGFβ, and galectin-9 concentrations. In addition, ccDC derived from this IEC/DC coculture enhanced Th1 and regulatory mediator secretion mimicking known in vivo effects.

Keyphrases

liver fibrosis
liver injury
drug induced
dna methylation
transforming growth factor
dendritic cells
signaling pathway