Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development.

Ting-Ting YuQiu-Fan XuSi-Yang LiHui-Jie HuangSarah DuganLei ShaoJennifer A RoggenbuckXiao-Tong LiuHuai-Ze LiuBetsy A HirschShen YueChen LiuSteven Y Cheng

Published in: Cell & bioscience (2021)

This work demonstrates that DNM3OS is essential for preventing premature differentiation of chondrocytes required for bone growth through endochondral ossification.

Keyphrases

long noncoding rna
bone mineral density
soft tissue
bone loss
extracellular matrix
postmenopausal women