Survival Outcomes in T3 Laryngeal Cancers: Primary Total Laryngectomy vs. Concurrent Chemoradiation or Radiation Therapy-A Meta-Analysis.
Karthik Nagaraja RaoPrathamesh S PaiPrajwal Shrirang DangeLuiz Paulo KowalskiPrimoz StrojanAntti Aarni MäkitieOrlando Guntinas-LichiusKevin Thomas RobbinsJuan Pablo RodrigoAvraham EisbruchRobert P TakesRemco de BreeAndrés Coca-PelazCesare PiazzaCarlos-Miguel Chiesa-EstombaFernando LópezNabil F SabaAlessandra RinaldoAlfio FerlitoPublished in: Biomedicines (2023)
TL followed with adjuvant (chemo)radiation on indication and CRT with salvage surgery in reserve appear to have similar OS outcomes. Both resulted in better OS outcomes compared to RT alone in the treatment of T3 laryngeal cancers. If patients are unfit for chemotherapy, making CRT impossible, surgery may become the choice of treatment.
Keyphrases
- locally advanced
- radiation therapy
- minimally invasive
- end stage renal disease
- coronary artery bypass
- rectal cancer
- ejection fraction
- newly diagnosed
- chronic kidney disease
- photodynamic therapy
- early stage
- squamous cell carcinoma
- combination therapy
- coronary artery disease
- metabolic syndrome
- peritoneal dialysis
- adipose tissue
- cardiac resynchronization therapy
- left ventricular
- patient reported outcomes
- insulin resistance