A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Michael T BromanRangarajan D NadadurCarlos Perez-CervantesOzanna Burnicka-TurekSonja LazarevicAnna GamsBrigitte LaforestJeffrey D SteimleSabrina IddirZhezhen WangLinsin SmithStefan R MazurekHarold E OliveyPingzhu ZhouMargaret GadekKaitlyn M ShenZoheb KhanJoshua W M TheisenXinan Holly YangKohta IkegamiIgor R EfimovWilliam T PuChristopher R WeberElizabeth M McNallyEric C SvenssonIvan P MoskowitzPublished in: Circulation (2024)
Transcriptional changes in the atria observed in human HF directly antagonize the atrial rhythm gene regulatory network, providing a genomic link between HF and AF risk independent of atrial remodeling.
Keyphrases
- atrial fibrillation
- heart failure
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- acute heart failure
- transcription factor
- endothelial cells
- percutaneous coronary intervention
- copy number
- gene expression
- oxidative stress
- dna methylation
- acute coronary syndrome
- heart rate
- heat shock protein