Mammalian organ regeneration in spiny mice.
Daryl M OkamuraElizabeth D NguyenSarah J CollinsKevin YoonJoshua B GereMary C M Weiser-EvansDavid R BeierMark W MajeskyPublished in: Journal of muscle research and cell motility (2022)
Fibrosis-driven solid organ failure is a major world-wide health burden with few therapeutic options. Spiny mice (genus: Acomys) are terrestrial mammals that regenerate severe skin wounds without fibrotic scars to evade predators. Recent studies have shown that spiny mice also regenerate acute ischemic and traumatic injuries to kidney, heart, spinal cord, and skeletal muscle. A common feature of this evolved wound healing response is a lack of formation of fibrotic scar tissue that degrades organ function, inhibits regeneration, and leads to organ failure. Complex tissue regeneration is an extremely rare property among mammalian species. In this article, we discuss the evidence that Acomys represents an emerging model organism that offers a unique opportunity for the biomedical community to investigate and clinically translate molecular mechanisms of scarless wound healing and regeneration of organ function in a mammalian species.
Keyphrases
- wound healing
- spinal cord
- stem cells
- skeletal muscle
- high fat diet induced
- healthcare
- spinal cord injury
- mental health
- systemic sclerosis
- public health
- heart failure
- idiopathic pulmonary fibrosis
- machine learning
- liver failure
- metabolic syndrome
- risk factors
- early onset
- wild type
- neuropathic pain
- adipose tissue
- genetic diversity
- ischemia reperfusion injury
- climate change
- health information
- aortic dissection
- acute respiratory distress syndrome
- human health
- liver fibrosis