A novel syphilis Treponema pallidum lipoprotein peptide antigen diagnostic assay using red cell kodecytes in routine blood centre column agglutination testing platforms.
Suvro Sankha DattaRadhika NagappanDurba BiswasDebapriya BasuKaushik GuptaPradip Kumar MondalAlexander TuzikovNicolai V BovinStephen M HenryPublished in: Vox sanguinis (2024)
TmpA-kodecytes are viable for use as cost-effective serologic reagent red cells for the detection of treponemal antibodies to diagnose syphilis with a high level of specificity in blood centres. This kodecyte methodology also potentially allows for introduction of the reverse-algorithm testing into low-volume laboratories, by utilizing existing transfusion laboratory infrastructure.
Keyphrases
- men who have sex with men
- human immunodeficiency virus
- induced apoptosis
- single cell
- cell cycle arrest
- machine learning
- cell therapy
- clinical practice
- deep learning
- loop mediated isothermal amplification
- cell death
- stem cells
- sickle cell disease
- real time pcr
- cell proliferation
- label free
- sars cov
- antiretroviral therapy
- respiratory syndrome coronavirus
- pi k akt