Dendritic cells generated in the presence of interferon-α and modulated with dexamethasone as a novel tolerogenic vaccine platform.

Olga Leplina Yuliya D Kurochkina Marina Aleksandrovna Tikhonova Ekaterina Yakovlevna Shevela Aleksandr Anatolevich Ostanin Elena Removna Chernykh

Published in: Inflammopharmacology (2019)

The data obtained indicate that potent tDCs could be generated by treating IFN-DCs with dexamethasone. The tolerogenic properties of IFN-DCs/Dex are better than or at least equal to those of the IL-4-DCs/Dex, as assessed by in vitro phenotypic and functional assays, suggesting these cells as a new tolerogenic vaccine platform.

Keyphrases

dendritic cells
high throughput
immune response
regulatory t cells
induced apoptosis
high dose
low dose
cell cycle arrest
transcranial direct current stimulation
cell death
signaling pathway
anti inflammatory
cell proliferation
artificial intelligence