ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response.

Yifei LiuLei ZhangShumin ZhangJialu LiuXiaohui LiKexin YangDanyi YangYu LiuLin SunFuyou LiuLi Xiao

Published in: Molecular medicine (Cambridge, Mass.) (2023)

ATF5 could exert a protective effect in a very early stage but promoted tubulointerstitial injury by regulating HSP60 and the UPRmt pathway under DKD conditions, providing a potential target for the prevention of DKD progression.

Keyphrases

early stage
endoplasmic reticulum stress
transcription factor
type diabetes
oxidative stress
heat shock protein
protein protein
heat shock
wound healing
heat stress
risk assessment
human health
radiation therapy
small molecule
lymph node
neoadjuvant chemotherapy