High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity.
Natasja L de VriesVincent van UnenMarieke E IjsselsteijnTamim AbdelaalRuud van der BreggenArantza Farina SarasquetaAhmed MahfouzKoen C M J PeetersThomas HölltBoudewijn P F LelieveldtFrits KoningNoel F C C de MirandaPublished in: Gut (2019)
This work provides a blueprint for the understanding of the heterogeneous and intricate immune landscape of CRC, including the identification of previously unappreciated immune cell subsets. The concomitant presence of tumour-resident innate and adaptive immune cell populations suggests a multitargeted exploitation of their antitumour properties in a therapeutic setting.