Cholesterol-conjugated siRNAs silence gene expression in mucosal dendritic cells in cervicovaginal tissue in mice.
Emre BasarBennett ShumAdriane Skaletz-RorowskiYichao WuSandeep NambiarNorbert H BrockmeyerPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
As mucosal DCs play an essential role for mucosal viral entry and dissemination, chol-siRNAs could be harnessed to target various host factors that are critical for viral uptake, DC migration and trans-infection of virions to T cells, hence allowing the development of a preventive vaginal HIV microbicide. Furthermore, chol-siRNAs could help elucidate the pathways of HIV transmission and understand the immunologic function of DCs in the genital tract.
Keyphrases
- dendritic cells
- antiretroviral therapy
- hiv positive
- gene expression
- hiv testing
- hiv infected
- human immunodeficiency virus
- ulcerative colitis
- hepatitis c virus
- sars cov
- hiv aids
- men who have sex with men
- immune response
- regulatory t cells
- dna methylation
- photodynamic therapy
- type diabetes
- metabolic syndrome
- adipose tissue
- low density lipoprotein
- skeletal muscle