A novel neuregulin - jagged1 paracrine loop in breast cancer transendothelial migration.

Ramon M CabreraSerena P H MaoChinmay R SurveJohn S CondeelisJeffrey E Segall

Published in: Breast cancer research : BCR (2018)

This study demonstrates that stimulation of macrophages by tumor cell NRG1 can enhance transendothelial migration and intravasation. We also demonstrate that this effect is due to induction of macrophage JAG1, an important ligand of the Notch signaling pathway.

Keyphrases

signaling pathway
single cell
adipose tissue
cell therapy
pi k akt
stem cells
mesenchymal stem cells
breast cancer risk