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A novel neuregulin - jagged1 paracrine loop in breast cancer transendothelial migration.

Ramon M CabreraSerena P H MaoChinmay R SurveJohn S CondeelisJeffrey E Segall
Published in: Breast cancer research : BCR (2018)
This study demonstrates that stimulation of macrophages by tumor cell NRG1 can enhance transendothelial migration and intravasation. We also demonstrate that this effect is due to induction of macrophage JAG1, an important ligand of the Notch signaling pathway.
Keyphrases
  • signaling pathway
  • single cell
  • adipose tissue
  • cell therapy
  • pi k akt
  • stem cells
  • mesenchymal stem cells
  • breast cancer risk