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Elucidation of the molecular mechanism underlying the anti-inflammatory activity of an effective and safe bipyrazole-based compound.

Souraya A DomiatiM MehannaH RagabK H Abd El GalilH Nakkash-ChmaisseA El Mallah
Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)
These findings revealed the superiority of the newly synthesized bipyrazole compound not only on the binding site, but also by inhibiting most of the inflammatory mediators including TNF-α.
Keyphrases
  • rheumatoid arthritis
  • signaling pathway
  • oxidative stress
  • single cell