A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients.
Asimina SafarikaJames W WackerKonstantinos KatsarosNicky SolomonidiGeorge GiannikopoulosAntigone KotsakiIoannis M KoutelidakisSabrina M CoyleHenry K ChengOliver LiesenfeldTimothy E SweeneyEvangelos J Giamarellos-BourboulisPublished in: Intensive care medicine experimental (2021)
InSep demonstrated high accuracy for predicting the presence of both bacterial and viral infections in ED patients with suspected acute infections or suspected sepsis. When translated into a rapid, point-of-care test, InSep will provide ED physicians with actionable results supporting early informed treatment decisions to improve patient outcomes while upholding antimicrobial stewardship. Registration number at Clinicaltrials.gov NCT03295825.
Keyphrases
- emergency department
- end stage renal disease
- sars cov
- newly diagnosed
- primary care
- ejection fraction
- chronic kidney disease
- liver failure
- prognostic factors
- peritoneal dialysis
- pulmonary embolism
- patient reported outcomes
- adverse drug
- electronic health record
- smoking cessation
- sensitive detection
- loop mediated isothermal amplification