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Large-scale variation in single nucleotide polymorphism density within the laboratory axolotl (Ambystoma mexicanum).

Nataliya TimoshevskayaS Randal VossCaitlin N LabiancaCassity R HighJeramiah James Smith
Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)
Our findings show that axolotl genomes are variable with respect to introgressed DNA from a highly polymorphic species. It seems likely that other divergent regions will be discovered with additional sequencing of A mexicanum. This has practical implications for designing molecular probes and suggests a need to study A mexicanum phenotypic variation and genome evolution across the tiger salamander clade.
Keyphrases
  • single molecule
  • genome wide
  • gene expression
  • dna methylation
  • fluorescence imaging