Login / Signup

A cold case of hemolytic disease of the fetus and newborn resolved by genomic sequencing and population studies to define a new antigen in the Rh system.

Brett WilsonCandice L DavisonGenghis H LopezGlenda M MillardYew-Wah LiewTanya PowleyTamika CampbellSudhir S JadhaoShivashankar H NagarajMaree A PerryEileen V RoulisMaree ToombsDavid O IrvingRobert L FlowerCatherine A Hyland
Published in: Transfusion (2024)
This antibody was of clinical significance, resulting in a mild to moderate hemolytic disease of the fetus and newborn (HDFN). In the past, the cause of such HDFN cases may have remained unresolved. Genomic sequencing combined with population studies now assists in resolving such cases. Further population studies have potential to inform the need to design population-specific red cell antibody typing panels for antibody screening in the Australian population.
Keyphrases
  • single cell
  • stem cells
  • copy number
  • gene expression
  • risk assessment
  • climate change
  • human health