The Roles of hnRNP Family in the Brain and Brain-Related Disorders.
Caroline Brandão-TelesAndré S L M AntunesTalita Aparecida de Moraes VrechiDaniel Martins-de-SouzaPublished in: Molecular neurobiology (2023)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to a complex family of RNA-binding proteins that are essential to control alternative splicing, mRNA trafficking, synaptic plasticity, stress granule formation, cell cycle regulation, and axonal transport. Over the past decade, hnRNPs have been associated with different brain disorders such as Alzheimer's disease, multiple sclerosis, and schizophrenia. Given their essential role in maintaining cell function and integrity, it is not surprising that dysregulated hnRNP levels lead to neurological implications. This review aims to explore the primary functions of hnRNPs in neurons, oligodendrocytes, microglia, and astrocytes, and their roles in brain disorders. We also discuss proteomics and other technologies and their potential for studying and evaluating hnRNPs in brain disorders, including the discovery of new therapeutic targets and possible pharmacological interventions.
Keyphrases
- white matter
- resting state
- cell cycle
- multiple sclerosis
- functional connectivity
- cerebral ischemia
- bipolar disorder
- spinal cord injury
- mass spectrometry
- physical activity
- inflammatory response
- neuropathic pain
- cognitive decline
- high throughput
- climate change
- blood brain barrier
- optical coherence tomography
- mild cognitive impairment
- label free