The impact of lesional inflammatory cellular infiltrate on the phenotype of bullous pemphigoid.
Sascha StänderC M HammersA VorobyevEnno SchmidtD ZillikensS GhorbanalipoorK BieberR J LudwigKhalaf KridinPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2021)
Eosinophil-predominance and high cellularity in the lesional inflammatory infiltrate of BP skin are associated with increased seropositivity of anti-BP180 NC16A IgG. Lymphocyte-predominant infiltrates predict a more severe phenotype, pointing towards a pathogenic role of autoreactive lymphocytes.