Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia.
Juan C SalazarFabio Samir Vargas-CelyJonny Alejandro García LunaLady G RamirezEverton B BettinNelson Romero-RosasMaría F AmórteguiSebastián SilvaOscar OviedoJulie VigilCarson J La VakeXimena GalindoJose D RamirezÁlvaro José MartínezMelissa J CaimanoChristopher M HennellyFarhang AghakhanianM Anthony MoodyArlene C SeñaJonathan B ParrKelly L HawleyEduardo Lopez MedinaJustin D RadolfPublished in: PloS one (2024)
This study offers new insights into the sociodemographic and clinical features of venereal syphilis in a highly endemic area of Colombia and illustrates how genomic sequencing of regionally prevalent TPA strains can inform vaccine development.