Vof16-miR-185-5p-GAP43 network improves the outcomes following spinal cord injury via enhancing self-repair and promoting axonal growth.

Yue HuYi-Fei SunHao YuanJia LiuLi ChenDong-Hui LiuYang XuXin-Fu ZhouLi DingZe-Tao ZhangLiu-Lin XiongLu-Lu XueTing-Hua Wang

Published in: CNS neuroscience & therapeutics (2024)

Our data indicated miR-185-5p could be a detrimental factor in SCT, and vof16 may function as a ceRNA by competitively binding miR-185-5p to modulate GAP43 in the process of self-recovery after SCT. Our study revealed a novel vof16-miR-185-5p-GAP43 regulatory network in neurological self-repair after SCT and may underlie the potential treatment target for SCI.

Keyphrases

spinal cord injury
spinal cord
neuropathic pain
long non coding rna
electronic health record
transcription factor
single cell
big data
risk assessment
network analysis
blood brain barrier
artificial intelligence