Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction.

Alec DavilaYanna TianIstvan CzikoraAmanda S WeissmanNicholas WeinandGuangkuo DongJiean XuJie LiHuabo SuGaston KapukuYuqing HuoZsolt Bagi

Published in: Microcirculation (New York, N.Y. : 1994) (2020)

Our results indicate that ADK inhibition selectively enhances microvascular vasodilator function, whereby it improves LV perfusion and LV contractile function under metabolic and hemodynamic stress.

Keyphrases

blood pressure
skeletal muscle
left ventricular
oxidative stress
heart failure
tyrosine kinase
coronary artery
smooth muscle