Impaired Bile Secretion Promotes Hepatobiliary Injury in Sickle Cell Disease.
Ravi VatsSilvia LiuJunjie ZhuDhanunjay MukhiEgemen TutuncuogluNayra CardenesSucha SinghTomasz BrzoskaKaris KosarMikhil BamneJude JonassaintAdeola Adebayo MichaelSimon C WatkinsCheryl HilleryXiaochao MaKari Nejak-BowenMauricio RojasMark T GladwinGregory J KatoSadeesh RamakrishnanPrithu SunddSatdarshan Paul MongaTirthadipa Pradhan-SunddPublished in: Hepatology (Baltimore, Md.) (2020)
These findings identify that NF-κB/FXR-dependent impaired bile secretion promotes intrahepatic bile accumulation, which contributes to hepatobiliary injury of SCD. Improved understanding of these processes could potentially benefit the development of therapies to treat sickle cell hepatic crisis.