The Rare-Earth Elements Doping of BaGdF 5 Nanophosphors for X-ray Photodynamic Therapy.
Daria KirsanovaVladimir PolyakovVera V ButovaPeter ZolotukhinAnna BelanovaZaira GadzhimagomedovaMikhail A SoldatovIlia PankinAlexander V SoldatovPublished in: Nanomaterials (Basel, Switzerland) (2021)
It is known that the initiation of photodynamic therapy (PDT) in deep-seated tumors requires the use of X-rays to activate the reactive oxygen species generation in deep tissues. The aim of this paper is to synthesize X-ray nanophosphors and analyze their structural and luminescence characteristics to push the PDT process deep into the body. The article deals with BaGdF 5 :Eu 3+ , BaGdF 5 :Sm 3+ , and BaGdF 5 :Tb 3+ nanophosphors synthesized using microwave synthesis. It is found that the nanoparticles are biocompatible and have sizes 5-17 nm. However, according to the analysis of X-ray excited optical luminescence, BaGdF 5 :Sm 3+ nanophosphors will not be effective for treating deep-seated tumors. Thus, BaGdF 5 :Eu 3+ and BaGdF 5 :Tb 3+ nanoparticles meet the requirements for the subsequent production of nanocomposites based on them that can be used in X-ray photodynamic therapy.
Keyphrases
- photodynamic therapy
- high resolution
- dual energy
- fluorescence imaging
- reactive oxygen species
- mycobacterium tuberculosis
- quantum dots
- electron microscopy
- energy transfer
- gene expression
- computed tomography
- magnetic resonance imaging
- magnetic resonance
- reduced graphene oxide
- drug release
- transition metal
- electron transfer