Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis.
Simon Licht-MayerGraham R CampbellArpan R MehtaKatie McGillAlex SymondsSarah Al-AzkiGareth PryceStephanie E J ZandeeChao ZhaoMarkus KippKenneth J SmithDavid BakerDaniel AltmannStephen M AndertonYolanda S KapJon D LamanBert A 't HartMoses RodriguezRobin J M FranklinSiddharthan ChandranHans LassmannBruce D TrappDon J MahadPublished in: Neuropathology and applied neurobiology (2022)
Our findings indicate that ARMD is a consistent and prominent feature and emphasise the importance of complex IV activity in the context of ARMD, especially in autoimmune inflammatory demyelination, paving the way for the development of novel neuroprotective therapies.