Briarenols Q-T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908).

Yi-Lin ZhangChih-Chao ChiangYi-Ting LeeZhi-Hong WenYang-Chang WuYu-Jen WuTsong-Long HwangTung-Ying WuChia-Yuan ChangPing-Jyun Sung

Published in: Marine drugs (2020)

Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q-T (1-4). The structures of new metabolites 1-4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

Keyphrases

nitric oxide synthase
nitric oxide
endothelial cells
inflammatory response
ms ms
molecular docking
high resolution
anti inflammatory
mass spectrometry