Hyaluronic acid-alginate hydrogel stimulates the differentiation of neonatal mouse testicular cells into hepatocyte-like and other cell lineages in three-dimensional culture.

Leila Rashki GhalenoMohammad Amin HajariMahmoud Alipour ChoshaliElham Abed HeidariAbdolhossein Shahverdi Hiva AlipourMojtaba Rezazadeh Valojerdi

Published in: Biology of the cell (2024)

While the HA-Alg composite did not support spermatogenesis in the 3D culture of mouse testicular cells, it demonstrated an unpredicted potential for promoting the differentiation of neonate mouse testicular cells into HLC, erythrocytes, and other cell lineages.

Keyphrases

induced apoptosis
hyaluronic acid
cell cycle arrest
single cell
endoplasmic reticulum stress
drug delivery
cell therapy
oxidative stress
cell death
signaling pathway
stem cells
risk assessment
climate change
human health
liver injury