Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.
Crisma EmmanuelAli OranElizabeth T JensenRaina N FichorovaWilliam A GowerEliana M PerrinKeia SandersonAndrew M SouthSemsa GogcuJeffrey ShenbergerRachana SinghKartikeya MakkerAmanda L ThompsonHudson SantosRebecca C FryThomas Michael O'Sheanull nullPublished in: Pediatric research (2024)
In the large multi-center Extremely Low Gestational Age Newborn (ELGAN) cohort, sustained elevation of neonatal levels of inflammation-related proteins was not consistently associated with asthma or obesity outcomes at 10 or 15 years of age. This finding contrasts with reported associations of perinatal inflammation with obesity at 2 years and neurodevelopmental disorders at 2-15 years in the ELGANs, suggesting that unlike neurodevelopment, peripubertal obesity and asthma may be driven by later childhood exposures. Future research on perinatal mechanisms of childhood asthma and obesity should account for both fetal and later exposures and pathways in addition to inflammation at birth.
Keyphrases
- gestational age
- insulin resistance
- metabolic syndrome
- weight loss
- oxidative stress
- high fat diet induced
- type diabetes
- chronic obstructive pulmonary disease
- weight gain
- lung function
- birth weight
- preterm birth
- allergic rhinitis
- pregnant women
- adipose tissue
- low birth weight
- skeletal muscle
- preterm infants
- young adults
- pregnancy outcomes